Christian Doppler first described the Doppler effect based on the changes in frequencies of light and sound produced by a changing relationship between two objects. Doppler ultrasound now provides practitioners with a noninvasive method to study fetal and placental hemodynamics. Doppler assessment of fetal circulation allows for the detection of pathologic rearrangements that occur in response to fetal hypoxemia, fetal growth restriction, and fetal anemia. Meanwhile, Doppler assessment of the placental circulation plays an important role in screening for impaired placentation and its complications, such as preeclampsia, fetal growth restriction, and stillbirth. Novel use of three-dimensional (3D) power Doppler allows for investigation of morbidly adherent placentation. Doppler ultrasound continues to evolve to give practitioners a better understanding of the pathophysiology of a wide range of pathological pregnancies and their clinical management.
Doppler C. Uber das farbige. Licht der Dopplersterne und einigr anderer Gestirne des Himmels. (On the coloured light of double stars and certain other stars of the heavens). Royal Bohemian Society 1842;2:465.
Callen P. Ultrasonography in Obstetrics and Gynecology. 5th ed. Saunders Elsevier; 2008.
Hoffman S, Galan H. Assessing the ‘at-risk’ fetus: Doppler ultrasound. Curr Opin Obstet Gynecol 2009;21:161–166. DOI: 10.1097/GCO.0b013e3283292468
Stuart B, Drumm J, Fitzgerald D, et al. Fetal blood velocity waveforms in normal pregnancy. Br J Obstet Gynaecol 1980;87(9):780–785. DOI: 10.1111/j.1471-0528.1980.tb04613.x
Alfirevic Z, Neilson J. Doppler ultrasonography in high-risk pregnancies: systematic review with meta-analysis. Am J Obstet Gynecol 1995;172(5):1379–1387. DOI: 10.1016/0002-9378(95)90466-2
Kontopoulous E, Quintero R, Chmait R, et al. Percent absent end-diastolic velocity in the umbilical artery waveform as a predictor of intrauterine fetal demise of the donor twin after selective laser photocoagulation of communicating vessels in twin-twin transfusions syndrome. Ultrasound Obstet Gynecol 2007;30(1):35–39. DOI: 10.1002/uog.4055
Mari G, Adrignolo A, Abuhamad Z, et al. Diagnosis of fetal anemia with Doppler ultrasound in the pregnancy complicated by maternal blood group isoimmunization. Ultrasound Obstet Gynecol 1995;5(6):400–405. DOI: 10.1046/j.1469-0705.1995.05060400.x
American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 75: management of alloimmunization. Obstet Gynecol 2006;108(2):457–464. DOI: 10.1097/00006250-200608000-00044
Mari G, Hanif F, Kruger M, et al. Middle cerebral artery peak systolic velocity: a new Doppler parameter in the assessment of growth-restricted fetuses. Ultrasound Obstet Gynecol 2007;29(3):310–316. DOI: 10.1002/uog.3953
Ghidini A, Locatelli A. Monitoring of fetal well-being: role of uterine artery Doppler. Semin Perinatol 2008;32:258–262. DOI: 10.1053/j.semperi.2008.04.019
Phupong V, Dejthevaporn T. Predicting risks of preeclampsia and small for gestational age infant by uterine artery Doppler. Hypertens Pregnancy 2008;27:387–395. DOI: 10.1080/10641950801958059
Onwudiwe N, Yu C, Poon L, et al. Prediction of preeclampsia by a combination of maternal history, uterine artery Doppler and mean arterial pressure. Ultrasound Obstet Gynecol 2008;32(7):877–883. DOI: 10.1002/uog.6124
Li H, Gudnason H, Olofsson P, et al. Increased uterine artery vascular impedance is related to adverse outcome of pregnancy but is present in only one-third of late third-trimester pre-eclamptic women. Ultrasound Obstet Gynecol 2005;25(5):459–463. DOI: 10.1002/uog.1895
Ferrazzi E, Bulfamante G, Mezzopane R, et al. Uterine Doppler velocimetry and placental hypoxic-ischemic lesion in pregnancies with fetal intrauterine growth restriction. Placenta 1999;20(5-6):389–394. DOI: 10.1053/plac.1999.0395
McCowan L, North R, Harding J. Abnormal uterine artery Doppler in small-for-gestational-age pregnancies is associated with later hypertension. Aust N Z J Obstet Gynaecol 2001;41(1):56–60. DOI: 10.1111/j.1479-828x.2001.tb01294.x
Abuhamad A, Mari G, Copel J, et al. Umbilical artery flow velocity waveforms in monoamniotic twins with cord entanglement. Obstet Gyencol 1995;86(4 Pt 2):674–677. DOI: 10.1016/0029-7844(95)00210-i
Abuhamad A, Sclater A, Carlson E, et al. Umbilical artery Doppler waveform notching: is it a marker for cord and placental abnormalities? J Ultrasound Med 2002;21(8):857–860. DOI: 10.7863/jum.2002.21.8.857
Baschat A, Harman C. Venous Doppler in the assessment of fetal cardiovascular status. Curr Opin Obstet Gynecol 2006;18:156–163. DOI: 10.1097/01.gco.0000192988.07471.f9
Rizzo G, Capponi A, Talone P, et al. Doppler indices from inferior vena cava and ductus venosus in predicting pH and oxygen tension in umbilical blood at cordocentesis in growth retarded fetuses. Ultrasound Obstet Gynecol 1996;7(6):401–410. DOI: 10.1046/j.1469-0705.1996.07060401.x
Baschat A, Guclu S, Kush M, et al. Venous Doppler in the prediction of acid-base status of growth-restriction fetuses with elevated placental blood flow resistance. Am J Obstet Gynecol 2004;191(1):277–284. DOI: 10.1016/j.ajog.2003.11.028
Schawarze A, Gembruch U, Krapp M, et al. Qualitative venous Doppler flow waveform analysis in preterm intrauterine growth-restricted fetuses with ARED flow in the umbilical artery—correlation with short term outcome. Ultrasound Obstet Gynecol 2005;25(6):573–579. DOI: 10.1002/uog.1914
Mari G, Hanif F, Treadwell M, et al. Gestational age at delivery and Doppler waveforms in very preterm intrauterine growth-restricted fetuses as predicators of perinatal mortality. J Ultrasound Med 2007;26(5):555–559. DOI: 10.7863/jum.2007.26.5.555
Rizzo G, Arduini D, Romanini C. Umbilical vein pulsations: a physiologic finding in early gestation. Am J Obstet Gynecol 1992;167(3):675–677. DOI: 10.1016/s0002-9378(11)91569-5
Mari G, Hanif F. Fetal Doppler: umbilical artery, middle cerebral artery and venous system. Semin Perinatol 2008;32(4):253–257. DOI: 10.1053/j.semperi.2008.04.007
Hofstaetter C, Hansmann M, Eik-Nes S, et al. A cardiovascular profile score in the surveillance of fetal hydrops. J Matern Fetal Neonatal Med 2006;19(7):407–413. DOI: 10.1080/14767050600682446
Bellotti M, Pennati G, De Gasperi C, et al. Simultaneous measurements of umbilical venous, fetal hepatic and ductus venosus blood flow in growth-restricted human fetuses. Am J Obstet Gynecol 2004;190(5):1347–1358. DOI: 10.1016/j.ajog.2003.11.018
McDicken W, Anderson T. The difference between colour Doppler velocity imaging and power Doppler imaging. Eur J Echocardiography 2002;3:240–244. DOI: 10.1053/euje.2002.0150
Fortunato S. The use of power Doppler and color power angiography in fetal imaging. Am J Obstet Gynecol 1996;174:1828–1833. DOI: 10.1016/s0002-9378(96)70217-x
Guerriero S, Ajossa S, Mais V, et al. Color Doppler energy imaging in the diagnosis of fetal intracranial hemorrhage in the second trimester. Ultrasound Obstet Gynecol 1997;10(3):205–208. DOI: 10.1046/j.1469-0705.1997.10030205.x
Pilu G, Falco P, Milani V, et al. Prenatal diagnosis of micrcophaly assisted by vaginal sonography and power Doppler. Ultrasound Obstet Gynecol 1998;11(5):357–360. DOI: 10.7863/jum.1996.15.11.785
Fox D, Bruner J, Fleischer A. Amplitude-based color Doppler sonography of fetus with sacrococcygeal teratoma. J Ultrasound Med 1996;15:785–787. DOI: 10.7863/jum.1996.15.11.785
Chua L, Twining P. A comparison of power colour flow with frequency based color flow Doppler fetal echocardiography. Clin Radiol 1997;52(9):712–714. DOI: 10.1016/s0009-9260(97)80038-4
DeVore G. The value of color Doppler sonography in the diagnosis of renal agenesis. J Ultrasound Med 1995;14(6):443–449. DOI: 10.7863/jum.1995.14.6.443
Chou M, Ho E, Lee Y. Prenatal diagnosis of placenta previa accreta by transabdominal color Doppler ultrasound. Ultrasound Obstet Gynecol 2000;15(1):28–35. DOI: 10.1046/j.1469-0705.2000.00018.x
Devesa R, Munoz A, Torrents M, et al. Prenatal diagnosis of vasa previa with transvaginal color Doppler ultrasound. Ultrasound Obstet Gynecol 1996;8(2):139–141. DOI: 10.1046/j.1469-0705.1996.08020137-3.x
Chaoui R, Kalache K, Hartung J. Application of three-dimensional power Doppler ultrasound in prenatal diagnosis. Ultrasound Obstet Gynecol 2001;17:22–29. DOI: 10.1046/j.1469-0705.2001.00305.x
Pairleitner H, Steiner H, Hasenoehrl G, et al. Three-dimensional power Doppler sonography: imaging and quantifying blood flow and vascularization. Ultrasound Obstet Gynecol 1999;14:139–143. DOI: 10.1046/j.1469-0705.1999.14020139.x
Pretorius DH, Nelson TR, Baergen RN, et al. Imaging of placental vasculature using three-dimensional ultrasound and color power Doppler: a preliminary study. J Perinat Med 2002;30:48–56. DOI: 10.1046/j.1469-0705.1998.12010045.x
Chaoui R, Hoffmann J, Heling KS. Three-dimensional (3D) and 4D color Doppler fetal echocardiography using spatio-temporal image correlation (STIC). Ultrasound Obstet Gynecol 2004;23:535–545. DOI: 10.1002/uog.1075
Matijevic R, Kurjak A. The assessment of placental blood vessels by three-dimensional power Doppler ultrasound. J Perinat Med 2002;30:26–32. DOI: 10.1515/JPM.2002.004
Shih JC, Ko TL, Lin MC, et al. Quantitative three-dimensional power Doppler ultrasound predicts the outcome of placental chorioangioma. Ultrasound Obstet Gynecol 2004;24:202–206. DOI: 10.1002/uog.1081
Hartung J, Kalache KD, Chaoui R. Three-dimensional power Doppler ultrasonography (3D-PDU) in fetal diagnosis. Ultraschall Med 2004;25:200–205. DOI: 10.1055/s-2004-813090
Ritchie CJ, Edwards WS, Mack LA, et al. Three-dimensional ultrasonic angiography using power-mode Doppler. Ultrasound Med Biol 1996;22:277–286. DOI: 10.1016/0301-5629(95)02052-7
Zalud I, Shaha S. Evaluation of the uteroplacental circulation by three-dimensional Doppler ultrasound in the second trimester of normal pregnancy. J Matern Fetal Neonatal Med 2007;20(4):299–305. DOI: 10.1080/14767050601158206
Zalud I, Shaha S. Three-dimensional sonography of the placenta and uterine spiral vasculature: influence of maternal age and parity. J Clin Ultrasound 2008;36(7):391–396. DOI: 10.1002/jcu.20485
Merce L, Barco M, Bau S, et al. Assessment of placental vascularization by three-dimensional power Doppler “Vascular Biospy” in normal pregnancies. Croat Med J 2005;465:765–771.
Bartha J, Moya E, Hervias-Vivancos B. Three-dimensional power Doppler analysis of cerebral circulation in normal and growth restricted fetuses. J Cereb Blood Flow Metab 2009;29(9):1609–1618. DOI: 10.1038/jcbfm.2009.70
Kalache K, Romero R, Goncalves L, et al. Three-dimensional color power imaging of the fetal hepatic circulation. Am J Obstet Gynecol 2003;189(3):1401–1406. DOI: 10.1067/s0002-9378(03)00774-9
Miller D, Chollet J, Goodwin T. Clinical risk factors for placenta previa-placenta accreta. Am J Obstet Gynecol 1997;177:210–214. DOI: 10.1016/s0002-9378(97)70463-0
Warhak C, Ramos G, Eskander R, et al. Effect of predelivery diagnosis in 99 consecutive cases of placenta accreta. Obstet Gynecol 2010;115(1):65–69. DOI: 10.1097/AOG.0b013e3181c4f12a
Shih J, Jaraquemada P, Su Y, et al. Role of three-dimensional power Doppler in the antenatal diagnosis of placenta accreta: comparison with gray-scale and color Doppler techniques. Ultrasound Obstet Gynecol 2009;33:193–203. DOI: 10.1002/uog.6284