Donald School Journal of Ultrasound in Obstetrics and Gynecology

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VOLUME 16 , ISSUE 1 ( January-March, 2022 ) > List of Articles

REVIEW ARTICLE

Preimplantation Genetic Diagnosis

Elitza Markova-Car, Krešimir Pavelić

Keywords : Embryo, Microarray, Next generation sequencing, Preimplantation genetic diagnosis

Citation Information : Markova-Car E, Pavelić K. Preimplantation Genetic Diagnosis. Donald School J Ultrasound Obstet Gynecol 2022; 16 (1):79-82.

DOI: 10.5005/jp-journals-10009-1920

License: CC BY-NC 4.0

Published Online: 22-04-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Preimplantation genetic diagnosis (PGD) or preimplantation genetic screening (PGS) is an early form of prenatal diagnosis which allows that, before the pregnancy has begun, embryos can be tested for genetic disorders.1 The rationale behind the method lies in the removal of cells from early embryos and genetic analysis of these cells before being transferred to the uterus. This procedure offers an advantage for those couples having genetic disorders whose offspring has an increased risk of a specific genetic condition by helping in the delivery of a healthy baby or prevention of repeated spontaneous abortions.2 As a result, PGS has developed as a valuable tool for enhancing pregnancy success with assisted reproductive technologies.3 In fact, PGD may possibly be suggested for any disorder for which molecular testing can be performed.


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