Cerebral palsy (CP) is the most common motor disability in childhood. It affects 2 to 2.5 children in 1000 live-births, with 20 to 30 fold increased prevalence in preterm infants. Despite of progress in perinatal care, the prevalence of cerebral palsy did not change in the last 50 years. New knowledge about etiological factors, such as inflammation, elevated level of cytokines, vascular strokes and genetic factors shift the origin of cerebral palsy mostly into antenatal period, making intrapartal damage responsible for less than 10% of cases. CP is becoming increasingly the subject of interdisciplinary research. Fetal neurosonography with a growing number of studies promises better understanding of the normal functional maturation of the human brain which may lead to effective prevention and treatment of cerebral palsy. Advances in 4D ultrasound resulted in development of KANET as tool for detection of abnormal fetal behavior.
New scoring system for fetal neurobehavior assessed by three and four-dimensional sonography. J Perinat Med 2008;36(1):73-81.
Purposed definition and classification of cerebral palsy, April 2005. Dev Med Child Neurol 2005;47:571-76.
Cerebral palsy. N Engl Med 1994; 330:188-95.
The changing epidemiology of cerebral palsy. Arch Dis Child Fetal Neonatal Ed 1996;75:169-73
Perinatal glucocorticoid therapy and neurodevelopmental outcome: An epidemiologic perspective. Neonatol 2001;7:293-307.
Effect of magnesium sulfate given for neuroprotection before preterm birth: A randomized controlled trial. J Am Med Ass 2003;290:2669-76.
Use of the GMFCS in infants with CP: The need for reclassification at age 2 years or older. Dev Med Child Neurol 2009;51:46-52.
Clinical assessment of spasticity in children with cerebral palsy: A critical review of available instruments. Dev Med Child Neurol 2006;48: 64-73.
ABILHANDkids: A measure of manual ability in children with cerebral palsy. Neurology 2004;63(6):1045-52.
A standard form recording clinical findings in children with motor deficit of central origin. Dev Med Child Neurol 1989;31:119-22.
Surveillance of cerebral palsy in Europe: A collaboration of cerebral palsy surveys and register. Dev Med Child Neurol 2000;42:816-24.
William John Little and CP in the nineteenth century. J Hist Med Allied Sci 1989;44(1)56-71.
Hystorical perspectives on the Etiology of CP. Clinics in Perinatology 2006;33(2):233-50.
Infections diseases in pregnancy, cytokines and neurological impairment: A hypothesis. Dev Med Child Neurol 1993;35:549-55.
Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obs Gynecol 2000;182(3):675-81.
Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia. Am Journal of Obstetrics and Gynecology 1996;174(5):1433-40.
Chorioamnionitis and cerebral palsy in term and near- term infants. JAMA 2003;26:2677-84.
Diagnosis of perinatal TORCH infection. Clin Obstet Gynecol 1999;42:59-70.
Molecular genetics in fetal brain. In: Fetal Neurology. Pooh RK, Kurjak A (Eds). Jaypee Brothers: New Delhi 2009;453-83.
Interleukin-6 genotype and risk for cerebral palsy in term and near-term infants. Ann Neurol 2009;66(5):663-70.
Apolipoprotein E and functional recovery from brain injury following postacute rehabilitation. Neurology 2000;55:1536-39.
Association of Apolipoprotein E Genotype and Cerebral Palsy in Children. Pediatrics 2007;119(2):306-13.
Preterm labour and delivery: A genetic predisposition. Pediatr perinat Epidemiol 2001;15(2):57-62.
Genetic polymorphisms and spontaneous preterm birth. Obstet Gynecol 2007;109:384-39.
Genetic syndromes associated with cerebral palsy. Clin Orthop Relat Res 1974;99:2-11.
A gene for autosomal recessive symmetrical spastic cerebral palsy maps to chromosome 2q24-25. Am J Hum Genet 1999;64:256-532.
Outcomes of children with infantile spasms after perinatal stroke. Pediatr Neurol 2006;34(4):291-95.
Perinatal arterial stroke. Understanding of mechanisms and outcomes. Semin Neurol 2005;25(4):424-34.
Fetal stroke. Pediatr Neurol 2004;30(3):151-62.
Thrombophilias, perinatal stroke and cerebral palsy. Clin Obstet Gynecol 2006;49:875-78.
Adverse pregnancy outcomes are associated with multiple maternal thrombophilic factors. Eur J Obstet Rep Biol 2004;117:144-47.
Cerebral Palsy and the application of the international criteria for acute intrapartum hypoxia. Obstet Gynecol 2006;107:1357-65.
Cerebral Palsy and Multiple Births. Dev Med Child Neurol 2002;44:352-55.
The risk of mortality of cerebral palsy in twins: A collaborative population based study. Pediatr Res 2002:52(5):671-81.
Consequences of in utero death in twin pregnancy. Lancet 2000;355:1597-1602.
A hypothesis for the etiology of spastic cerebral palsy in vanishing twin. Dev Med Child Neurol 1997;30:292-96.
Neurological sequale in in-vitro fertilization babies. Lancet 2002;360(9334):718-19.
Neonatal signs as predictors of cerebral palsy. Pediatrics 1979;64:225.
Neonatal neurodevelopmental examination as a predictor of neuromotor outcome in premature infants. Pediatrics 1989;83:498.
Manual for the assessment of preterm infants’ behavior (APIB). In: Theory and Research in Behavioral Pediatrics, Fitzgerald H, Lester B, Yogman M (Eds), Plenum Press, New York, 65.
The neurological examination of the full term infant (2nd ed): London, 1977.
Predictive value of neonatal neurological tests for developmental outcome of preterm infants. J Pediatr 2000;137:100-06.
Update of the Amiel-Tison neurologic assessment for the term neonate or at 40 weeks corrected age. Pediatr Neurol Sep 2002;27(3):196-212.
Assessment of Fetal Neurobehavior by 3D/4D ultrasound. Fetal Neurology 2009;8:221-87.
Are there behavioural states in the human fetus? Early Hum Dev 1982;12:99-120.
Is neurological assessment of the fetus possible? Eur Jour Obstet Gynecol 1997;75:81-84.
Qualitative changes of spontaneous movements in fetus and preterm infant are a marker of neurological dysfunction. Early Hum Dev 1990;23:151-58.
How useful is 3D and 4D ultrasound in perinatal medicine? J Perinat Med 2002;30:57-62.
Normal standards for fetal neurobehavioral developmentlongitudinal quantification by four-dimensional sonography. J Perinat Med 2006;34:56-65
Fetal hand movements and facial expression in normal pregnancy studied by fourdimensional sonography. J Perinat Med 2003;3:496-501.
The potential of 4D sonography in the assessment of fetal neurobehavior –multicentric study in high-risk pregnancies. J Perinat Med 2010;38(1):77-82.
Neurological assessment of the neonate revisited: A personal view. Dev Med Child Neurol 1990; 32:1105-1113.
Neurosonography in the second half of the fetal life: A neonatologists point of view. J Perinat Med 2006;34:437-446.
Behavioral pattern continuity from prenatal to postnatal life-a study by four-dimensional (4D) ultrasonography. J Perinat Med 2004;32:346-53.