Citation Information :
Leung K, Cheong K, Tang M. 2D and 3D Ultrasound Prediction of Homozygous α0-Thalassemia. Donald School J Ultrasound Obstet Gynecol 2010; 4 (2):123-126.
Conventionally, prenatal diagnosis is achieved by an invasive procedure followed by DNA analysis or hematological study. With experienced hand and a good ultrasound machine, a noninvasive approach consisting of serial two-dimensional ultrasound examinations of cardiothoracic ratio and placenta thickness can effectively reduce the need for invasive testing in the majority of unaffected pregnancies. Although middle cerebral artery peak systolic velocity (MCAPSV) is a well-established sonographic marker for predicting fetal anemia due to Rhesus isoimmunization, it is not clear whether MCAPSV is useful in the prediction of affected pregnancies. Preliminary studies have been performed to investigate the use of 3D ultrasound in the prediction of pregnancies affected by homozygous α0-thalassemia. It seems that 3D is not superior to 2D ultrasound prediction of affected pregnancies.
Ultrasound measurement of placental thickness to detect pregnancies affected by homozygous α-thalassemia-1. Lancet 1994;344: 988-89.
Early ultrasound prediction of pregnancies affected by homozygous α-thalassemia-1. Prenat Diagn 1997;17:327-32.
Cost-effectiveness of prenatal screening for thalassemia in Hong Kong. Prenat Diagn 2004;24:899-907.
Placental thickness at midpregnancy as a predictor of Hb Bart's disease. Prenat Diagn 1999;19:1027-30.
A new strategy for prenatal diagnosis of homozygous alpha-thalassaemia. Ultrasound Obstet Gynecol 2006;28:173-77.
Ultrasound evaluation of pregnancies at risk for homozygous alpha-thalassaemia-1. Prenat Diagn 1987;7:307-13.
Second trimester hydrops fetalis in pregnancies affected by homozygous alphathalassemia-1. Prenat Diagn 1997;17:267-69.
Serial sonographic findings of four fetuses with homozygous alpha-thalassemia-1 from 21 weeks onwards. Ultrasound Obstet. Gynecol 2002;19: 56-59.
Prenatal diagnosis of alpha-thalassemia in a twin pregnancy. Ultrasound Obstet Gynecol 2005;25:201-02.
Use of placental volume measured by three-dimensional ultrasound for the prediction of fetal Hb-Bart's disease: A preliminary report. Ultrasound Obstet. Gynecol 2006;28:166-72.
Detection of increased middle cerebral artery peak systolic velocity in fetuses affected by hemoglobin H Quong Sze disease. Ultrasound Obstet Gynecol 2004;23:523-26.
Middle cerebral artery Doppler study in fetuses with homozygous α-thalassemia-1 at 12-13 weeks of gestation. Prenat Diagn 2002;22:56-58.
Ultrasonographic prediction of homozygous alpha-thalassemia using placental thickness, fetal cardiothoracic ratio and middle cerebral artery Doppler: Alone or in combination? Ultrasound Obstet Gynecol Feb 2010;35:149-54.
Sonographic diagnosis of limb reduction defects in a fetus with haemoglobin Bart's disease at 12 weeks of gestation. Prenat Diagn 1999;19:983-85.
Echogenic bowel in fetuses with homozygous alpha-thalassemia-1 in the first and second trimesters. Ultrasound Obstet Gynecol 1999;14:180-82.
Nuchal translucency in fetuses affected by homozygous alpha-thalassemia-1 at 12-13 weeks of gestation. Ultrasound Obstet Gynecol 1999;13: 238-40.
Cardiac blood flow studies in fetuses with homozygous alpha-thalassemia-1 at 12-13 weeks of gestation. Ultrasound Obstet Gynecol 1999;13:48-51.
Ductus venosus Doppler study in fetuses with homozygous alpha-thalassemia-1 at 12 to 13 weeks of gestation. Ultrasound Obstet Gynecol 2001;17:30-33.
Use of placental volume measured by three-dimensional ultrasound for the prediction of fetal Hb-Bart's disease: A preliminary report. Ultrasound Obstet Gynecol 2006;28:166-72.
Early ultrasound prediction of pregnancies affected by homozygous α-thalassemia-1. Prenat Diagn 1997;17:327-32.
Prenatal ultrasonographic prediction of homozygous type 1 alpha-thalassemia at 12-13 weeks of gestation. Am J Obstet Gynecol 1999;180: 148-50.
Cost-effectiveness of prenatal screening for thalassemia in Hong Kong. Prenat Diagn 2004;24:899-907.
Prenatal diagnosis of alpha-thalassaemia in a twin pregnancy. Ultrasound Obstet Gynecol 2005;25:201-02.
Experience in preimplantation genetic diagnosis for exclusion of homozygous alpha degrees thalassemia. Prenat Diagn 2006; 26:1029-36.
Quantitative polymerase chain reaction for the rapid prenatal diagnosis of homozygous alpha-thalassemia (Hb Bart's hydrops fetalis). Br J Haematol 2001;115:341-46.
