Donald School Journal of Ultrasound in Obstetrics and Gynecology

Register      Login

VOLUME 4 , ISSUE 1 ( January-March, 2010 ) > List of Articles

REVIEW ARTICLE

CMV Infection in Pregnancy

William Goh, Lynnae Sauvage

Keywords : Cytomegalovirus,congenital infections,CMV hyperimmunoglobulin

Citation Information : Goh W, Sauvage L. CMV Infection in Pregnancy. Donald School J Ultrasound Obstet Gynecol 2010; 4 (1):43-50.

DOI: 10.5005/jp-journals-10009-1128

License: CC BY-NC 4.0

Published Online: 01-03-2010

Copyright Statement:  Copyright © 2010; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Objectives

Understand why CMV is an important cause of congenital injections

Understand the role of ultrasound in the diagnosis of intrauterine CMV infections

Understand the possible treatment options for a fetus infected with CMV


PDF Share
  1. Congenital cytomegalovirus infections. Semin Fetal Neonatal. Med 2007; 12(3):154-59.
  2. Human cytomegalovirus structural proteins. J Gen Virol 1994;75:3287-308.
  3. Primary cytomegalovirus infection in pregnancy. Incidence, transmission to fetus, and clinical outcome. JAMA 1986;256(14):1904-08.
  4. Secondary cytomegalovirus infection can cause severe fetal sequelae despite maternal preconceptual immunity. Ultrasound Obstet Gynecol 2008;31(4):417-20.
  5. Allogeneic transplantation induces expression of Cytomegalovirus immediate-early genes in vivo: A model for reactivation from latency. J Virol 2001;75(10):4814-22.
  6. Spread of human cytomegalovirus (HCMV) after Infection of human hematopoietic progenitor cells: Model of HCMV latency. Blood 1997;90(6):2483-91.
  7. Reactivation of human herpesvirus 6 during pregnancy. J Infect Dis 1999;180(6):2035-38.
  8. Intrauterine transmission of cytomegalovirus to infants of women with preconceptual immunity. NEJM 2001;344(18):1366-71.
  9. Primary versus nonprimary cytomegalovirus infection during pregnancy, Israel. Emerg Infec Dis 2007;13(11): 1791-93.
  10. Longitudinal, serological study of cytomegalovirus infections in nurses and in personnel without patient contact. J Clin Microbiol 1975;2(5):448-52.
  11. Washing our hands of the congenital cytomegalovirus disease epidemic. BMC Public Health. 2005;5:70.
  12. Maternal-fetal cytomegalovirus infection: From diagnosis to therapy. J Matern Fetal Neonatal Med 2009; 22(2):169-74.
  13. Epidemiologic characteristics of cytomegalovirus infection in mothers and their infants. Am J Obstet Gynecol 1988;158(5):1189-95.
  14. Fetal effects of primary and secondary cytomegalovirus infection in pregnancy. Reprod Toxicol 2006;21(4):399-409.
  15. Epidemiology of transmission of cytomegalovirus from mother to preterm infant by breastfeeding. Lancet 2001; 357(9255):513-18.
  16. Clinical manifestations and abnormal laboratory findings in pregnant women with primary cytomegalovirus infection. BJOG 2003;110(6):572-77.
  17. Primary cytomegalovirus infection in pregnancy. JAMA 1986;256(14):1904-08.
  18. The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. MEJM 1992;326(10):663-67.
  19. Evaluation of the new architect cytomegalovirus immunoglobulin M (IgM), IgG and IgG avidity assays. J Clin Microbiol. 2009;47(6): 1695-99.
  20. Congenital cytomegalovirus infection in twin pregnancies: Viral load in the amniotic fluid and pregnancy outcome. Pediatrics 2003;112(2):153-57.
  21. Prenatal diagnosis of symptomatic congenital cytomegalovirus infection. Am J Obstet Gynecol 2000; 183(2): 476-82.
  22. Prenatal diagnosis of fetal cytomegalovirus infection after primary or recurrent maternal infection. Obset Gynecol 1999;94(6):909-14.
  23. Sonographic finding in fetal viral infections: A systemic review. Obset Gynecol Surv 2006;61(5):329-36.
  24. Cytomegalovirus-related fetal brain lesions: Comparison between targeted ultrasound examination and magnetic resonance imaging. Ultrsound Obstet Gynecol 2008;32(7):900-05.
  25. Comparison between ultrasound and magnetic resonance imaging in assessment of fetal cytomegalovirus infection. Prenat Diagn 2008;28:753-58.
  26. Pharmacokinetic and pharmacodynamic assessement of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease. J Infect Dis. 2008;197(6):836-45.
  27. Oral valganciclovir for symptomatic congenital cytomegalovirus infection in an extremely low birthweight infant. J Perinatol. 2008;28(1): 74-76.
  28. Successful use of oral ganciclovir for the treatment of intrauterine cytomegalovirus infection in a renal allograft recipient. Transpl Infect Dis. 2005;7(2):71-74.
  29. Absence of teratogencity of oral ganciclovir used during early pregnancy in a liver transplant recipient. Transplantation. 1999;67(5):758-59.
  30. Severe cytomegalovirus hepatitis in a pregnant woman treated with ganciclovir. Scand J Infect Dis. 1998;30:304-05.
  31. Maternal administration of Valaciclovir in symptomatic intrauterine cytomegalovirus infection. BJOG. 2007;114(9):1113-21.
  32. Resolution of hydrops secondary to cytomegalovirus after maternal and fetal treatment with human cytomegalovirus hyperimmune globulin. Obstet Gynecol 2008;111 (2, part 2):524-26.
  33. Regression of fetal cerebral abnormalities by primary cytomegalovirus infection following hyperimmunoglobulin therapy. Prenat Diagn 2008;28(6):512-17.
  34. Passive immunization during pregnancy for congenital cytomegalovirus infection. MEJM 2005;353(13):1350-62.
  35. Findings and conclusions from CMV hyperimmune globulin treatment trials. J Clin Virol. 2009 Dec;46 Suppl 4:S54-7 Epub 24 Sep 2009.
  36. Vaccine development to prevent cytomegalovirus disease: A report from the National Vaccine Advisory Committee. Clin Infect Dis 2004;39(2): 233-39.
  37. Vaccine prevention of maternal cytomegalovirus infection. MEJM 2009;360(12):1191-99.
  38. Randomized, double-blind, phase 1 trial of an alphavirus replicon vaccine for cytomegalovirus in CMV seronegative adult volunteers. Vaccine 2009;28(2):484-93 Epub 24 Oct 2009.
  39. DNA vaccines expressing glycoprotein complex II antigens gM and gN elicited neutralizing antibodies against multiple human cytomegalovirus (HCMV) isolates. Vaccine. 2007;25(17):3319-27.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.