Donald School Journal of Ultrasound in Obstetrics and Gynecology

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VOLUME 18 , ISSUE 3 ( July-September, 2024 ) > List of Articles

CASE REPORT

Maturity-onset Diabetes of the Young During Pregnancy

Konstantinos Tasias, Panagiotis Antsaklis, Athena Souka, Marianna Theodora, George Asimakopoulos, George Daskalakis

Keywords : Case report, Glucokinase-related maturity-onset diabetes of the young, Maturity-onset diabetes of the young, Pregnancy

Citation Information : Tasias K, Antsaklis P, Souka A, Theodora M, Asimakopoulos G, Daskalakis G. Maturity-onset Diabetes of the Young During Pregnancy. Donald School J Ultrasound Obstet Gynecol 2024; 18 (3):307-310.

DOI: 10.5005/jp-journals-10009-2033

License: CC BY-NC 4.0

Published Online: 30-09-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Maturity-onset diabetes of the young (MODY) is a rare form of diabetes that is different from both type 1 and type 2 diabetes and runs strongly in families, with autosomal dominant inheritance. Currently, there are 14 different types of MODY depending on the gene disorder. Glucokinase-related MODY (MODY 2) is a common form of this disorder. Mutations in the gene are associated with gestational diabetes and deviation of the average fetal birth weight. The main features of MODY are: (1) diabetes developing before the age of 25 years, (2) family history, (3) diabetes treated by diet or less often by tablets, and (4) absence of obesity (although overweight or obese people can get MODY) or other problems associated with type 2 diabetes or metabolic syndrome. We present the case of a 35-year-old Caucasian primigravida with a medical and family history of MODY type 2, who attended our unit due to fetal growth restriction (FGR) and increased umbilical artery (UA) Doppler pulsatility index (PI) at 28 weeks of gestation and delivered at 36+6 weeks. Management of such cases requires specific knowledge and a multidisciplinary approach.


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