The female reproductive system in humans is a finely balanced highly dynamic hormonal system. Correct understanding of these hormonal orchestras is the basis of understanding the cause of infertility and it is the same understanding that helps to manage the treatment cycles optimally. This can be done by multiple hormonal assessments, but ultrasound is a very effective tool to monitor, follow, and understand these changes and this is sonoendocrinology. The vascular changes precede the morphological changes when hormonal changes occur. Correlating the morphological and vascular changes with their physiological and hormonal basis can interpret the hormonal changes occurring during the menstrual cycle.
Jonard S, Robert Y, Cortet-Rudelli C, et al. Ultrasound examination of polycystic ovaries: is it worth counting the follicles? Hum Reprod 2003;18(3):598–603. DOI: 10.1093/humrep/deg115
Raju GA, Chavan R, Deenadayal M, et al. Luteinizing hormone and follicle stimulating hormone synergy: a review of role in controlled ovarian hyper-stimulation. J Hum Reprod Sci 2013;6(4):227–234. DOI: 10.4103/0974-1208.126285
Battaglia C, Battaglia B, Morotti E, et al. Two- and three-dimensional sonographic and color Doppler techniques for diagnosis of polycystic ovary syndrome. The stromal/ovarian volume ratio as a new diagnostic criterion. J Ultrasound Med 2012;31(7):1015–1024. DOI: 10.7863/jum.2012.31.7.1015
Ozkan S, Vural B, Caliskan E, et al. Color Doppler sonographic analysis of uterine and ovarian artery blood flow in women with polycystic ovary syndrome. J Clin Ultrasound 2007;35(6):305–313. DOI: 10.1002/jcu.20358
Haadsma ML, Bukman A, Groen H, et al. The number of small antral follicles (2-6 mm) determines the outcome of endocrine ovarian reserve tests in a subfertile population. Hum Reprod 2007;22(7):1925–1931. DOI: 10.1093/humrep/dem081
Van Rooij IA, Broekmans FJ, te Velde ER, et al. Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve. Hum reprod 2002;17(12):3065–3071. DOI: 10.1093/humrep/17.12.3065
Hehenkamp WJ, Looman CW, Themmen AP, et al. Anti-Müllerian hormone levels in the spontaneous menstrual cycle do not show substantial fluctuation. J Clin Endocrinol Metab 2006;91(10):4057–4063. DOI: 10.1210/jc.2006-0331
La MArca A, Stabile G, Artenisio AC, et al. Serum anti-Mullerian hormone throughout the human menstrual cycle. Hum Reprod 2006;21(12):3103–3107. DOI: 10.1093/humrep/del291
ER te Velde et al. Advances in fertility studies and reproductive medicine IFFS 2007; 306.
Gruijters MJ, Visser JA, Durlinger AL, et al. Anti-Müllerian hormone and its role in ovarian function. Mol cell Endocrinol 2003;211(1-2):85–90. DOI: 10.1016/j.mce.2003.09.024
Panchal S, Nagori C. Comparison of anti-Mullerian hormone and antral follicle count for assessment of ovarian reserve. J Hum Reprod Sci 2012;5(3):274–278. DOI: 10.4103/0974-1208.106340
Aflatoonian A, Oskouian H, Ahmadi S, et al. Prediction of high ovarian response to controlled ovarian hyperstimulation: anti-Mullerian hormone versus small antral follicle count (2–6 mm). J Assist Reprod Genet 2009;26(6):319–325. DOI: 10.1007/s10815-009-9319-5
Broer SL, Mol BW, Hendriks D, et al. The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count. Fertil Steril 2009;91(3):705–714. DOI: 10.1016/j.fertnstert.2007.12.013
Loverro G, Vicino M, Lorusso F, et al. Polycystic ovary syndrome: relationship between insulin sensitivity, sex hormone levels and ovarian stromal blood flow. Gynecol Endocrinol 2001;15(2):142–149. DOI: 10.1080/gye.15.2.142.149
Hendriks DJ, Mol BW, Bancsi LF, et al. Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: a meta-analysis and comparison with basal follicle-stimulating hormone level. Fertil Steril 2005;83(2):291–301. DOI: 10.1016/j.fertnstert.2004.10.011
Battaglia C, Artini PG, Salvatori M, et al. Ultrasonographic patterns of polycystic ovaries: color Doppler and hormonal correlations. Ultrasound Obstet Gynecol 1998;11(5):332–336. DOI: 10.1046/j.1469-0705.1998.11050332.x
Battaglia C, Artini PG, D'Ambrogio G, et al. The role of color Doppler imaging in the diagnosis of polycystic ovary syndrome. Am J Obstet Gynecol 1995;172(1 Pt 1):108–113. DOI: 10.1016/0002-9378(95)90094-2
Lam PM, Johnson IR, Raine-Fenning NJ. Three-dimensional ultrasound features of the polycystic ovary and the effect of different phenotypic expressions on these parameters. Hum Reprod 2007;22(12):3116–3123. DOI: 10.1093/humrep/dem218
Legro RS, Chiu P, Kunselman AR, et al. Polycystic ovaries are common in women with hyperandrogenic chronic anovulation but do not predict metabolic or reproductive phenotype. J Clin Endocrinol Metab 2005;90(5):2571–2579. DOI: 10.1210/jc.2004-0219
Buckett WM, Bouzayen R, Watkin KL, et al. Ovarian stromal echogenicity in women with normal and polycystic ovaries. Hum Reprod 1999;14(3):618–621. DOI: 10.1093/humrep/14.3.618
Franks S, Webber LJ, Goh M, et al. Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries. J Clin Endocrinol Metab 2008;93(9):3396–3402. DOI: 10.1210/jc.2008-0369
Lam PM, Raine-Fenning N. The role of three-dimensional ultrasonography in polycystic ovary syndrome. Hum Reprod 2006;21(9):2209–2215. DOI: 10.1093/humrep/del161
Zaidi J, Barber J, Kyei-Mensah A, et al. Relationship of ovarian stromal blood flow at the baseline ultrasound scan to subsequent follicular response in an in vitro fertilization program. Obstet Gynecol 1996;88(5):779–784. DOI: 10.1016/0029-7844(96)00316-X
Abd El Aal DE, Mohamed SA, Amine AF, et al. Vascular endothelial growth factor and insulin-like growth factor-1 in polycystic ovary syndrome and their relation to ovarian blood flow. Eur J Obstet Gynecol reprod Biol 2005;118(2):219–224. DOI: 10.1016/j.ejogrb.2004.07.024
Willis D, Mason H, Gilling-Smith C, et al. Modulation by insulin of follicle-stimulating hormone and luteinizing hormone actions in human granulosa cells of normal and polycystic ovaries. J Clin Endocrinol Metab 1996;81(1):302–309. DOI: 10.1210/jcem.81.1.8550768
Pellatt L, Rice S, Dilaver N, et al. Anti-Müllerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells. Fertil Steril 2011;96(5):1246–1251.e1. DOI: 10.1016/j.fertnstert.2011.08.015
Merce LT, Barco MJ, Bau S, et al. Prediction of ovarian response and IVF/ICSI outcome by three-dimensional ultrasonography and power Doppler angiography. Eur J Obstet Gynecol Reprod Biol 2007;132(1):93–100. DOI: 10.1016/j.ejogrb.2006.07.051
Ng EH, Chan CC, Yeung WS, et al. Effect of age on ovarian stromal flow measured by three-dimensional ultrasound with power Doppler in Chinese women with proven fertility. Hum Reprod 2004;19(9):2132–2137. DOI: 10.1093/humrep/deh387
Humaidan P, Alviggi C, Fischer R, et al. The novel POSEIDON stratification of ‘Low prognosis patients in Assisted Reproductive Technology’ and its proposed marker of successful outcome. F1000Res 2016;5:2911. DOI: 10.12688/f1000research.10382.1
Dogan MM, Uygur D, Alkan RN, et al. Prediction of pituitary down-regulation by evaluation of endometrial thickness in an IVF programme. Reprod Biomed Online 2004;8(5):595–599. DOI: 10.1016/s1472-6483(10)61109-1
Jokubkiene L, Sladkevicius P, Rovas L, et al. Assessment of changes in volume and vascularity of the ovaries during the normal menstrual cycle using three-dimensional power Doppler ultrasound. Hum Reprod 2006;21(10):2661–2668. DOI: 10.1093/humrep/del211
Campbell S, Bourne TH, Waterstone J, et al. Transvaginal color blood flow imaging of the periovulatory follicle. Fertil Steril 1993;60(3):433–438.
Kupesic S, Kurjak A. Uterine and ovarian perfusion during the periovulatory period assessed by transvaginal color Doppler. Fertil Steril 1993;60(3):439–443. DOI: 10.1016/s0015-0282(16)56157-3
Bourne TH, Jurkovic D, Waterstone J, et al. Intrafollicular blood flow during human ovulation. Ultrasound Obstet Gynecol 1991;1(1):53–59. DOI: 10.1046/j.1469-0705.1991.01010053.x
Tan SL, Zaidi J, Campbell S, et al. Blood flow changes in the ovarian and uterine arteries during the normal menstrual cycle. Am J Obstet Gynecol 1996;175(3 Pt 1):625–631. DOI: 10.1053/ob.1996.v175.a73865
Bassil S, Magritte JP, Roth J, et al. Uterine vascularity during stimulation and its correlation with implantation in in-vitro fertilization. Hum Reprod 1995;10(6):1497–1501. DOI: 10.1093/humrep/10.6.1497
Smith B, Porter R, Ahuja K, et al. Ultrasonic assessment of endometrial changes in stimulated cycles in an in vitro fertilization and embryo transfer program. J In Vitro Fert Embryo Transf 1984;1(4):223–238. DOI: 10.1007/BF01131622
Applebaum M. The steel or Teflon endometrium-ultrasound visualization of endometrial vascularity in IVF patients and outcome. Presented at the third world congress of ultrasound in Obstetrics and gynecology. Ultrasound Obstet Gynecol 1993;3(Suppl 2):10.
Ng EH, Chan CC, Tang OS, et al. Relationship between uterine blood flow and endometrial and subendometrial blood flows during stimulated and natural cycles. Fertil Steril 2006;85(3):721–727. DOI: 10.1016/j.fertnstert.2005.09.051
Graham CH, Postovit LM, Park H, et al. Adriana and Luisa Castellucci award lecture 1999: role of oxygen in the regulation of trophoblast gene expression and invasion. Placenta 2000;21(5-6):443–450. DOI: 10.1053/plac.2000.0543
Ng EH, Chan CC, Tang OS, et al. The role of endometrial and subendometrial blood flows measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during IVF treatment. Hum Reprod 2006;21(1):164–170. DOI: 10.1093/humrep/dei277
Fevold HL. Synergism of follicle stimulating and luteinizing hormone in producing oestrogen secretion. J Clin Endocrinol Metab 1941;21.
Short RV. Steroids in the follicular fluid and the corpus luteum of the mare. A ‘two-cell type’ theory of ovarian steroid synthesis. J Endocrinology 1962;24:59–63. DOI: 10.1677/joe.0.0240059
Chui DK, Pugh ND, Walker SM, et al. Follicular vascularity–the predictive value of transvaginal power Doppler ultrasonography in an in-vitro fertilization programme: a preliminary study. Hum Reprod 1997;12(1):191–196. DOI: 10.1093/humrep/12.1.191
Nargund G, Bourne T, Doyle P, et al. Associations between ultrasound indices of follicular blood flow, oocyte recovery and preimplantation embryo quality. Hum Reprod 1996;11(1): 109–113. DOI: 10.1093/oxfordjournals.humrep.a019000
Van Blerkom J, Davis P, Alexander S. Inner mitochondrial membrane potential (DeltaPsim), cytoplasmic ATP content and free Ca2+ levels in metaphase II mouse oocytes. Hum Reprod 2003;18(11):2429–2440. DOI: 10.1093/humrep/deg466
Zaidi J, Campbell S, Pittrof R, et al. Endometrial thickness, morphology, vascular penetration and velocimetry in predicting implantation in an in vitro fertilization program. Ultrasound Obstet Gynecol 1995;6(3):191–198. DOI: 10.1046/j.1469-0705.1995.06030191.x
Tsai YC, Chang JC, Tai MJ, et al. Relationship of uterine perfusion to outcome of intrauterine insemination. J Ultrasound Med 1996;15(9):633–636. DOI: 10.7863/jum.1996.15.9.633
Cacciatore B, Simberg N, Fusaro P, et al. Transvaginal Doppler study of uterine artery blood flow in in vitro fertilization-embryo transfer cycles. Fertil Steril 1996;66(1):130–134. DOI: 10.1016/s0015-0282(16)58400-3
Salle B, Bied-Damon V, Benchaib M, et al. Preliminary report of an ultrasonography and colour Doppler uterine score to predict uterine receptivity in an in-vitro fertilization programme. Hum Reprod 1998;13(6):1669–1673. DOI: 10.1093/humrep/13.6.1669
Glock JL, Brumsted JR. Color flow pulsed Doppler ultrasound in diagnosing luteal phase defect. Fertil Steril 1995;64(3): 500–504.
Kupesić S, Kurjak A, Vujisić S, et al. Luteal phase defect: comparison between Doppler velocimetry, histological and hormonal markers. Ultrasound Obstet Gynecol 1997;9(2): 105–112. DOI: 10.1046/j.1469-0705.1997.09020105.x
