Donald School Journal of Ultrasound in Obstetrics and Gynecology

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VOLUME 16 , ISSUE 2 ( April-June, 2022 ) > List of Articles


Ovarian Tissue Microfragmentation and Exposure to Autologous Growth Factors In Vitro and Reproductive Outcome after Orthotopic Retransplantation

Taib Delić, Emina Smajić, Aleksandra Pašić, Vahidin Katica, Džihan Abazović, Dušica Petrović, Aleksandar Ljubic, Amela Kereš

Keywords : Growth factors, Orthotopic ovarian transplantation, Primary ovarian insufficiency, Sterility

Citation Information : Delić T, Smajić E, Pašić A, Katica V, Abazović D, Petrović D, Ljubic A, Kereš A. Ovarian Tissue Microfragmentation and Exposure to Autologous Growth Factors In Vitro and Reproductive Outcome after Orthotopic Retransplantation. Donald School J Ultrasound Obstet Gynecol 2022; 16 (2):118-123.

DOI: 10.5005/jp-journals-10009-1930

License: CC BY-NC 4.0

Published Online: 05-07-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Generally speaking, it is estimated that infertility affects about 186 million people worldwide. Infertility is still considered to be a female social burden, even though male fertility can be regarded as a half, or even more, of all cases of global infertility. This review aims to analyze the literature regarding the influence of growth factors on ovarian tissue cells after in vitro exposure and the establishment of normal reproductive and endocrine function after retransplantation. Primary ovarian insufficiency (POI) is one of the possible causes of infertility in women, affecting about 1% of the general population. Some of the specifics of premature ovarian failure (POF) are amenorrhea, elevated gonadotropin levels in women under 40, and also hypoestrogenism. Procedures such as ovarian transplantations can in fact lead to fertility restoring and endocrine function restoring. Ovarian tissue transplantation can be put into two categories, based on the tissue type that is planned to be transplanted: as ovarian cortex transplantation or ovarian transplantation. The process of freezing-thawing ovarian tissue is well known and researched, but the usage of cryopreserved ovarian cortex in fertility restoration still remains a significant challenge. Total effects of growth factors must be explored to a larger extent, but it is certainly encouraging that the known results are, by this day, quite satisfying. The beneficial effect on later follicle development or fertility restoration has yet to be researched and fully established.

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