Preterm labor (PTL) is a global problem which is a complex disease with a high rate of morbidity and mortality, also has long-term consequences for the baby and the family. The well-known morbidities related to PTL are respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, retinopathy of prematurity, and anemia of prematurity. In a developing country, the management of PTL is limited by poor health systems, low education level of the mother, poor financial support, lack of facility and trained health personnel, and demographic barriers. This limitation leads to high morbidity and mortality of preterm birth, especially in developing countries. It is important to reduce the rate of preterm birth by preventing the event. Several risk factors have been identified and are avoidable and preventable, such as smoking, bacterial infection, poor nutritional status, and malnourished mothers. Strategies to prevent PTL have been proposed in primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth.
Romero R, Espinoza J, Kusanovic J, et al. The preterm parturition syndrome. BJOG 2006;113(Suppl 3):17–42. DOI: 10.1111/j.1471-0528.2006.01120.x.
Requejo JH, Merialdi M. The global impact of preterm birth. In: Berghella V, ed. Preterm birth prevention and management. West Sussex: Blackwell Publishing; 2010. p. 1–7.
Blencowe H, Cousens S, Oestergaard MZ, et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet 2012;379(9832):2162–2172. DOI: 10.1016/S0140-6736(12)60820-4.
Treyvaud K. Parent and family outcomes following very preterm or very low birth weight birth: a review. Semin Fetal Neonat Med 2014;19(2):131–135. DOI: 10.1016/j.siny.2013.10.008.
Hansen M, Bower C. The impact of assisted reproductive technologies on intra-uterine growth and birth defects in singletons. Semin Fetal Neonatal Med 2014;19(4):228–233. DOI: 10.1016/j.siny.2014. 03.002.
March of Dimes, PMNCH, Save the Children, WHO. Born too soon: the global action report on preterm birth. Geneva: 2012.
Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science 2014;345(6198):760–765. DOI: 10.1126/science.1251816.
Tallandini MA, Morsan V, Macagno F. Preterm birth and assisted reproductive technology/ART: maternal emotional wellbeing and quality of mother–newborn interaction during the first three months of life. Early Hum Dev 2012;88(6):397–402. DOI: 10.1016/j.earlhumdev.2011.10.003.
Beer C, Israel C, Johnson S, et al. Twin birth: an additional risk factor for poorer quality maternal interactions with very preterm infants? Early Hum Dev 2013;89(8):555–559. DOI: 10.1016/j.earlhumdev.2013.02.006.
Brubaker SG, Gyamfi C. Prediction and prevention of spontaneous preterm birth in twin gestations. Semin Perinatol 2012;36(3):190–194. DOI: 10.1053/j.semperi.2012.02.003.
Miller ES, Grobman WA. The association between cervical excisional procedures, midtrimester cervical length, and preterm birth. Am J Obstet Gynecol 2014;211(3):242.e1-e4. DOI: 10.1016/j.ajog.2014.03.004.
Almario CV, Seligman NS, Dysart KC, et al. Risk factors for preterm birth among opiate-addicted gravid women in a methadone treatment program. Am J Obstet Gynecol 2009;201(3):326.e1-e6. DOI: 10.1016/j.ajog.2009.05.052.
Been JV, Lievense S, Zimmermann LJ, et al. Chorioamnionitis as a risk factor for necrotizing enterocolitis: a systematic review and meta-analysis. J Pediatr 2013;162(2):236–42.e2. DOI: 10.1016/j.jpeds.2012.07.012.
Flood K, Malone FD. Prevention of preterm birth. Semin Fetal Neonat Med 2012;17(1):58–63. DOI: 10.1016/j.siny.2011.08.001.
Murphy DJ. Epidemiology and environmental factors in preterm labour. Best Pract Res Clin Obstet Gynaecol 2007;21(5):773–789. DOI: 10.1016/j.bpobgyn.2007.03.001.
Shah R, Mullany LC, Darmstadt GL, et al. Incidence and risk factors of preterm birth in a rural Bangladeshi cohort. BMC Pediatr 2014;14(1):112. DOI: 10.1186/1471-2431-14-112.
Nour NM. An introduction to maternal mortality. Rev Obstet Gynecol 2008;1(2):77–81.
Salihu HM, Mbah AK, Alio AP, et al. Low pre-pregnancy body mass index and risk of medically indicated versus spontaneous preterm singleton birth. Eur J Obstet Gynecol Reprod Biol 2009;144(2):119–123. DOI: 10.1016/j.ejogrb.2009.02.047.
Stock SJ, Oyston C, Norman JE. Management of a woman with a previous preterm birth. Obstet, Gynaecol Reprod Med 2013;23(2):53–58. DOI: 10.1016/j.ogrm.2013.01.001.
Czeizel AE, Puho EH, Langmar Z, et al. Possible association of folic acid supplementation during pregnancy with reduction of preterm birth: a population-based study. Eur J Obstet Gynecol Reprod Biol 2010;148(2):135–140. DOI: 10.1016/j.ejogrb.2009.10.016.
Carr D, Koontz G, Gardella C, et al. Diabetic nephropathy in pregnancy: suboptimal hypertensive control associated with preterm delivery. Am J Hypertens 2006;19(5):513–519. DOI: 10.1016/j.amjhyper.2005.12.010.
Chatterjee J, Gullam J, Vatish M, et al. The management of preterm labour. Arch Dis Child Fetal Neonatal Ed 2007;92(2):F88–F93. DOI: 10.1136/adc.2005.082289.
Hamilton SA, Tower CL. Management of preterm labour. Obstet, Gynaecol Reproduc Med 2010;20(8):235–240. DOI: 10.1016/j.ogrm.2010.04.007.
DeFranco EA, Lewis DF, Odibo AO. Improving the screening accuracy for preterm labor: is the combination of fetal fibronectin and cervical length in symptomatic patients a useful predictor of preterm birth? a systematic review. Am J Obstet Gynecol 2013;208(3):233.e1-e6. DOI: 10.1016/j.ajog.2012.12.015.
Salomon LJ, Diaz-Garcia C, Bernard JP, et al. Reference range for cervical length throughout pregnancy: non-parametric LMS-based model applied to a large sample. Ultrasound Obstet Gynecol 2009;33(4):459–464. DOI: 10.1002/uog.6332.
Hurst HM, Linton DM. Preconception care: planning for the future. J Nurse Practition 2015;11(3):335–340. DOI: 10.1016/j.nurpra.2014.09.011.
Ko T-J, Tsai L-Y, Chu L-C, et al. Parental smoking during pregnancy and its association with low birth weight, small for gestational age, and preterm birth offspring: a birth cohort study. Pediatr Neonatol 2014;55(1):20–27. DOI: 10.1016/j.pedneo.2013.05.005.
Iams JD, Romero R, Culhane JF, et al. Primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth. Lancet 2008;371(9607):164–175. DOI: 10.1016/S0140-6736(08)60108-7.
Zhou Q, Zhang W, Xu H, et al. Risk factors for preterm premature rupture of membranes in Chinese women from urban cities. Int J Gynaecol Obstet 2014;127(3):254–259. DOI: 10.1016/j.ijgo.2014.06.020.
Danhof NA, Kamphuis EI, Limpens J, et al. The risk of preterm birth of treated versus untreated cervical intraepithelial neoplasia (CIN): a systematic review and meta-analysis. Eur J Obstet Gynecol Reproduct Biol 2015;188(0):24–33. DOI: 10.1016/j.ejogrb.2015.02.033.
Sungkar A, Purwosunu Y, Aziz MF, et al. Influence of early self-diagnosis and treatment of bacterial vaginosis on preterm birth rate. Int J Gynaecol Obstet 2012;117(3):264–267. DOI: 10.1016/j.ijgo.2012.01.007.
Romero R. Spontaneous preterm labor can be predicted and prevented. Ultrasound Obs Gyn 2021;57(1):19–21. DOI: 10.1002/uog.23565.
Goldenberg R, Culhane J, Iams J, et al. Epidemiology and causes of preterm birth. Lancet 2008;371(9606):75–84. DOI: 10.1016/S0140-6736(08)60074-4.