A Two-year Cross-sectional Prospective Study for Assessment of Endometrial Thickness and Volume using Three-dimensional Transvaginal Ultrasound among in vitro Fertilization Patients of Royan Institute in Iran
Firoozeh Ahmadi, Farnaz Akhbari, SH Irani, M Shiva, A Maghari
Citation Information :
Ahmadi F, Akhbari F, Irani S, Shiva M, Maghari A. A Two-year Cross-sectional Prospective Study for Assessment of Endometrial Thickness and Volume using Three-dimensional Transvaginal Ultrasound among in vitro Fertilization Patients of Royan Institute in Iran. Donald School J Ultrasound Obstet Gynecol 2016; 10 (4):398-402.
To evaluate the role of endometrial thickness and volume using three-dimensional transvaginal ultrasound (3-D TVUS) in order to predict pregnancy outcome in assisted reproductive technology (ART) cycle on the day of human chorionic gonadotropin (hCG) administration.
Materials and methods
In this prospective study, the long protocol of controlled ovarian hyperstimulation was prescribed for women. Endometrial thickness and volume were measured using the 3-D TVUS, for 166 women undergoing ART cycle, on the day of hCG administration at Royan Institute, Tehran, Iran, between 2009 and 2011. All patients were divided into three groups. Regarding endometrial thickness, there are three groups as follows: Group I: . 7 mm, group II: 7.14 mm, and group III: > 14 mm; all patients were also divided into three groups according to endometrial volume calculated as follows: Group IV: < 2 cc, group V: 2.4.5 cc, group VI: > 4.5 cc. Pregnancy rate (PR) was compared between all groups.
Results
A total of 166 patients were analyzed. Overall PR was 39.8% after in vitro fertilization (IVF). Participant's age ranged from 20 to 38 years old with the mean age of 29.9 ± 4.23. No significant cut-off value was found for endometrial thickness and volume.
Conclusion
Endometrial thickness and volume on the day of hCG are significant in limited value and in a clinical setting for predicting implantation in ART cycle.
How to cite this article
Ahmadi F, Akhbari F, Irani SH, Shiva M, Maghari A. A Two-year Cross-sectional Prospective Study for Assessment of Endometrial Thickness and Volume using Threedimensional Transvaginal Ultrasound among in vitro Fertilization Patients of Royan Institute in Iran. Donald School J Ultrasound Obstet Gynecol 2016;10(4):398-402.
Influence of embryo transfer depth on in vitro fertilization and embryo transfer outcomes. Fertil Steril 2004 Jan;81(1):51-58.
The role of ultrasonography in the evaluation of endometrial receptivity following assisted reproductive treatments: a critical review. Hum Reprod Update 1996 Jul-Aug;2(4):323-335.
Reliability of intraobserver and interobserver sonographic endometrial stripe thickness measurements. Fertil Steril 1998 Jul;70(1):152-154.
The effect of endometrial pattern and thickness on pregnancy rate in controlled ovarian hyperstimulation-intrauterine insemination. Med J Islamic Republic Iran 2005 Nov;19(3):189-193.
Three dimensional endometrial volume versus endometrial thickness measurement in prediction of IVF/ICSI outcome. Middle East Fertility Soc J 2005;10(1):63-67.
Endometrial thickness appears to be a significant factor in embryo implantation in in vitro fertilization. Hum Reprod 1995 Apr;10(4):919-922.
Endometrial pattern, thickness and growth in predicting pregnancy outcome following 3319 IVF cycle. Reprod Biomed Online 2014 Sep;29(3):291-298.
Three-dimensional endometrial volume calculation and pregnancy rate in an in vitro fertilization programme. Hum Reprod 1999 May;14(5):1255-1258.
Sonography of the endometrium during conception and nonconception cycles of in vitro fertilization and embryo transfer. Fertil Steril 1986 Sep;46(3):442-447.
Changes in endometrial thickness, width, length and pattern in predicting pregnancy outcome during ovarian stimulation in in vitro fertilization. Ultrasound Obstet Gynecol 2001 Sep;18(3):258-263.
Endometrial ultrasonography as a predictor of pregnancy in an in vitro fertilization programme after ovarian stimulation and gonadotrophin-releasing hormone and gonadotrophins. Human Reprod 1997 Nov;12(2):2515-2518.
Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow. Fertil Steril 2001 Feb;75(2):361-366.
A meta-analysis of the relationship between endometrial thickness and outcome of in vitro fertilization cycles. J Hum Reprod Sci 2011 Sep;4(3): 130-137.
Sonographic measurement of endometrium thickness as a predictive value for pregnancy through IVF. Ultraschall Med 2002 Aug;23(4):256-259 (German).
Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transfer: clues to endometrial receptivity. Hum Reprod 1999 Nov;14(11):2851-2854.