Donald School Journal of Ultrasound in Obstetrics and Gynecology

Register      Login

VOLUME 1 , ISSUE 2 ( April-June, 2007 ) > List of Articles

RESEARCH ARTICLE

Corpus Luteum Morphology and Vascularization Assessed by Transvaginal Two-dimensional and Three-dimensional Ultrasound

JM Bajo, B Gómez, P Álvarez, V Engels, A Martínez, J De la Fuente

Citation Information : Bajo J, Gómez B, Álvarez P, Engels V, Martínez A, De la Fuente J. Corpus Luteum Morphology and Vascularization Assessed by Transvaginal Two-dimensional and Three-dimensional Ultrasound. Donald School J Ultrasound Obstet Gynecol 2007; 1 (2):42-49.

DOI: 10.5005/jp-journals-10009-1098

License: CC BY-NC 4.0

Published Online: 01-06-2007

Copyright Statement:  Copyright © 2007; The Author(s).


Abstract

Background

Our aim was to describe the corpus luteum morphology by two-dimensional ultrasound correlated by its vascularization and volume by 3D ultrasound and study the possible relationship between serum progesterone levels and the corpus luteum morphology.

Methods

Thirty-eight women were included in an intrauterine insemination program (IUI) in Santa Cristina University's Hospital. All the patients were evaluated in mesoluteal phase, the day +7 after hCG administration, by two-dimensional and three-dimensional ultrasound. The volume and vascular indices of the corpus luteum were calculated off-line using virtual organ computer-aided analysis (VOCALTM) software.

Results

Four different morphologies were described in the corpus luteum: echo-positive, echo-negative or sonoluscent, mixed echogenicity or nonvisible. Corpus luteum with mixed echogenicity was the most frequent one with 37.5% (12 cases). The corpus luteum vascular indices change in each morphology type, but there was statistically significant association just in vascularization index between echo-negative and mixed echogenicity corpus luteum morphologies, with p = 0.034. The rest of vascular indices do not change in each morphology corpus luteum types. There was statistically significant difference in mean gray value between echo-negative and mixed echogenicity morphologies, with p = 0.007. There were no statistically significant correlations between the corpus luteum morphology and the corpus luteum volume of any of the different types. There either was no statistically significant correlation between the corpus luteum morphology and progesterone serum levels on day +7 postovulation.

Conclusions

The mixed echogenicity corpus luteum morphology has more vessels and more cell mass than echo-negative ones. Progesterone serum levels in mid-luteal phase has no influence in corpus luteum morphology and vascularization.


PDF Share
  1. Cyclic changes of vasculature and vascular phenotypes in normal human ovaries. Hum Reprod 1998;13,953-9.
  2. Angiogenesis in ovarian follicular and luteal development. Beilliteres Best Pract Res Clin Obstet Gynaicol 2000;14,883-900.
  3. Uterine and ovarian flow velocity waveforms in the normal menstrual cycle: a transvaginal Doppler study. Fertil Steril 1989;52,981-5.
  4. Blood flow changes of vasculature and vascular phenotypes in normal human menstrual cycle. Am J Obstet Gynecol 1996;175,625-31.
  5. Ultrasound studies of vascular and morphological changes in the human corpus luteum during the menstrual cycle. Fertil Steril 1996;65,753-8.
  6. Three-dimensional sonographic and power Doppler characterization of ovaries in late follicular phase. Ultrasound Obstet Gynecol 2002;20,281-5.
  7. Ovarian stroma flow intensity decreases by age: a three-dimensional power Doppler utrasonographic study. Ultrasound Med Biol 2002;28,425-30.
  8. Quantification of Doppler signal in polycystic ovary syndrome using three-dimensional power Doppler ultrasonography: a possible new marker for dignosis. Hum Reprod 2002;17,201-6.
  9. Sources and impact of artefacts on clinical three-dimensional ultrasound imaging. Ultrasound Obstet Gynecol 2000;16:374-83.
  10. Assessment of changes in volume and vascularity of the ovaries during the normal menstrual cycle using three-dimensional power Doppler ultrasound. Hum Reprod 2006;21(10):2661-8. Epub 2006 Jun 14.
  11. Endometrial volume and vascularity measurements by transvaginal three-dimensional ultrasound and power Doppler angiography in stimulated and tumoral endometria: Intraobserver reproducibility. Ultrasound Obstet Gynecol.
  12. Reproducibility of transvaginal three-dimensional endometrial volume measurements with virtual organ computer-aided analysis (VOCAL) during ovarian stimulation. Ultrasound Obstet Gynecol 2002;19:76-80.
  13. Intra and inter-observer reproducibility of the ovarian volume, follicle recount and vascular indices of ultrasounds and three-dimensional power doppler angiography processed by vocal imaging program. JUltrasound Med 2005;24(9):1279-87.
  14. Three-dimensional power Doppler sonography: imaging and quantigying blood flow and vascularization. Ultrasound Obstt Gynecol 1999;14,139-43.
  15. A quantitative study of changes in the human corpus luteum microvasculature during the menstrual cycle. Biol Reprod 1999;60,914-9.
  16. Investigation of the human corpus luteum by ultrasonography: a proposed scheme for clinical investigation. Ultrasound Obstet Gynecol 1992;2(3):190-6.
  17. Acta Obstet Gynecol Scand 1990;69(4):327-32.
  18. Rev Esp Fisiol 1989;45 (Suppl)125-31. Spanish.
  19. Doppler study of arterial and venous intraovarian blood flow in stimulated cycles. Ultrasound Obstet Gynecol 2001;18:505-10.
  20. The role of vascularization of the corpus luteum in the short luteal phase studied by Doppler ultrasound. Acta Obstet Gynecol Scand 1994;73:321-3.
  21. Estudio ecografico del ciclo ovarico normal. Ecografia Doppler en obstetricia y ginecologia. Madrid Interamericana- McGraw-Hill, 1993;91-112.
  22. Ultrasound Obstet Gynecol 1992;2,197-202.
  23. Three-dimensional ultrasound evaluation of ovarian masses. Gynecol Oncol 1995;59,129-35.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.